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Condensed Heterocyclic Compounds: Synthesis and Antiinflammatory Activity of Novel Thiazolo[3,2‐ a ]pyrimidines
Author(s) -
Tozkoparan Birsen,
Ertan Mevlüt,
Krebs Bernt,
Läge Mechtild,
Kelicen Pelin,
Demirdamar Rümeysa
Publication year - 1998
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(199806)331:6<201::aid-ardp201>3.0.co;2-t
Subject(s) - chemistry , stereochemistry , combinatorial chemistry
In this study, thirty six new 2‐benzylidene‐7‐methyl‐3‐oxo‐5‐phenyl‐2,3‐dihydro‐5 H ‐thiazolo[3,2‐ a ]pyrimidine‐6‐carboxylic acid methyl esters were synthesized and characterized by spectral, crystallographic, and elemental analysis. The antiinflammatory activity of the compounds was tested by the carrageenan hind paw edema test. It was found that compound 6a having a 2‐methoxyphenyl group at position 5 and a benzylidene group at position 2 was the most potent compound in this series. All the compounds that were tested for ulcer activity gave positive results.