Premium
Synthesis and Antibacterial Activities of New Carbapenems Having a Proline Reverse Amide Moiety at the C‐2 Position
Author(s) -
Hwang Soon Ho,
Shin Kye Jung,
Kang Yong Koo,
Kim Dong Jin,
Kim Dong Chan,
Yoo Kyung Ho,
Park Sang Woo,
Lee Kee Jung
Publication year - 1998
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/(sici)1521-4184(199804)331:4<139::aid-ardp139>3.0.co;2-u
Subject(s) - moiety , amide , chemistry , antibacterial activity , proline , stereochemistry , agar dilution method , agar dilution , antibacterial agent , chemical synthesis , organic chemistry , combinatorial chemistry , in vitro , bacteria , minimum inhibitory concentration , amino acid , biochemistry , antimicrobial , antibiotics , biology , genetics
The synthesis of new 1β‐methylcarbapenems ( 1a–l ) having a proline reverse amide moiety at the C‐2 position and their in vitro antibacterial activities are described. The compounds were evaluated by the Mueller‐Hinton agar dilution method and compared with meropenem as control. Aliphatic amides ( 1a–h ) are found to show greater antibacterial activity than aromatic amides ( 1i–l ). Moreover, C‐2 free amino compound ( 1m ) reveals greater activity than any other amide compounds ( 1a–l ).