Premium
Ligation of CD5 on resting B cells, but not on resting T cells, results in apoptosis
Author(s) -
Pers JacquesOlivier,
Jamin Christophe,
Corre Rozenn Le,
Lydyard Peter M.,
Youinou Pierre
Publication year - 1998
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/(sici)1521-4141(199812)28:12<4170::aid-immu4170>3.0.co;2-o
Subject(s) - biology , apoptosis , ligation , resting potential , microbiology and biotechnology , immunology , neuroscience , electrophysiology , genetics
Abstract The CD5 molecule is expressed by a B cell subset. We have demonstrated that resting B cells do not proliferate in response to CD5 ligation, whereas cells preactivated with anti‐IgM and IL‐2 do so. Here, we specifically studied the effects of anti‐CD5 and anti‐IgM on apoptosis of CD5 + B cells. Both ligation of CD5 or of surface IgM (sIgM) resulted in apoptosis. This started earlier following ligation of CD5 than with sIgM, and both responses were time dependent. CD5‐induced apoptosis was independent of the epitope recognized or the way the antibody was presented to the B cells. CD5 + B cells were more sensitive to IgM‐induced apoptosis than CD5 − B cells. Engagement of CD5 or CD3 expressed by T cells failed to induce apoptosis. Our data indicate differences in the function of CD5 molecules on tonsillar B cells, compared with blood T cells and suggest that cross‐linking CD5 on B cell activates specific pathways responsible for apoptosis.