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Modeling of the Performance of Industrial Bioreactors with a Dynamic Microenvironmental Approach: A Critical Review
Author(s) -
Guillard Fabrice,
Trägårdh Christian
Publication year - 1999
Publication title -
chemical engineering and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.403
H-Index - 81
eISSN - 1521-4125
pISSN - 0930-7516
DOI - 10.1002/(sici)1521-4125(199903)22:3<187::aid-ceat187>3.0.co;2-9
Subject(s) - bioreactor , aeration , mixing (physics) , biochemical engineering , process engineering , reliability (semiconductor) , process (computing) , environmental science , process development , environmental engineering , pulp and paper industry , computer science , chemistry , engineering , waste management , thermodynamics , physics , power (physics) , organic chemistry , quantum mechanics , operating system
Concentration gradients in industrial fed‐batch bioreactors due to imperfect mixing and biological consumption of nutrients result in a drastic decline in performance. Three advanced methods for the quantitative description of the mixing process in stirred, aerated tanks of industrial size are presented and commented on in terms of adequacy and reliability with regard to the microenvironmental approach, which gives biological and engineering factors the same importance.