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Electrochemical Studies of Vitamin K 3 Interacting with Hemoglobin and Determination of Hemoglobin
Author(s) -
Zhu Zhiwei,
Li NanQiang
Publication year - 1999
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/(sici)1521-4109(199911)11:15<1145::aid-elan1145>3.0.co;2-8
Subject(s) - hemoglobin , electrochemistry , chemistry , vitamin , electrode , inorganic chemistry , biochemistry
Electrochemical investigation of the interaction of vitamin K 3 (VK 3 ) with hemoglobin (Hb) on a Hg electrode is reported for the first time. With the addition of hemoglobin in vitamin K 3 solution, both the reduction and oxidation currents decrease but with no change of peak potentials. The reaction of vitamin K 3 with hemoglobin forms a kind of nonelectrochemical active supramolecular complex Hb–VK 3 . The equilibrium constant for complex is calculated as 3.75×10 4 . A satisfactory result has been obtained for the determination of hemoglobin in clinical blood samples.