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Plastic Membrane Selective Electrode for Cetirizinium Ion Based on Cetirizinium‐Tetraphenylborate Ion‐Pair
Author(s) -
Shoukry A. F.,
AbdelGhani N. T.,
Issa Y. M.,
Ahmed H. M.
Publication year - 1999
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/(sici)1521-4109(199905)11:6<443::aid-elan443>3.0.co;2-j
Subject(s) - tetraphenylborate , sodium tetraphenylborate , electrode , analytical chemistry (journal) , selectivity , chemistry , ion selective electrode , ion , reference electrode , titration , inorganic chemistry , electrolyte , chromatography , organic chemistry , catalysis
New cetirizinium (Cet) ion selective PVC membrane electrodes of both conventional and coated graphite types based on the ion‐pair of cetirizine with tetraphenylborate are prepared. Both electrodes exhibited a mean calibration plot slope of 66.8 mV/(Cet) concentration decade, at 25 °C, within the concentration range 3.16×10 –5 –3.16×10 –3 mol dm –3 Cet‐HCl 2 . The change of pH within the range (1.5–2.8) for 1.0×10 –3 mol dm –3 and 1.0×10 –4 mol dm –3 solutions and (2.25–3.25) for 1.0×10 –2 mol dm –3 solution does not affect the electrode performance. Outside the working pH‐ranges, the potential value decreases due to formation of diprotonated species on the acidic side and to formation of the free base on the alkaline side. The standard electrode potentials are determined at different temperatures and used to calculate the isothermal coefficient of the electrode (0.000875 V/°C). The electrode shows a very good selectivity for Cet‐HCl 2 with respect to a large number of inorganic cations and sugars where selectivity coefficients ranging between 7.0×10 –5 and 3.1×10 –3 were obtained. The standard addition method is successfully applied to determine Cet‐HCl 2 in pure solutions and in cetirizine dihydrochloride‐containing tablets.