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Electrochemical Behavior and In Vivo Determination of the Neurotransmitter Dopamine Using Sodium Montmorillonite Modified Electrodes
Author(s) -
Liju Yang,
Yang Catherine F.,
Tuzhi Peng,
Hangsheng Yang,
Cong Gao,
Guoqing Liu
Publication year - 1999
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/(sici)1521-4109(199905)11:6<438::aid-elan438>3.0.co;2-3
Subject(s) - cyclic voltammetry , microelectrode , glassy carbon , electrochemistry , electrode , chemistry , diffusion , sodium , voltammetry , analytical chemistry (journal) , chromatography , organic chemistry , physics , thermodynamics
A modified glassy carbon electrode is used to examine the mass transport characteristics of the neurotransmitter dopamine (DA) in sodium montmorillonite films. The apparent diffusion coefficient ( D app ) of DA in the film is measured by chronocoulometry and cyclic voltammetry to be 2.3×10 –9 and 5.1×10 –9 cm 2 /s. According to the Nicholson theory, the standard rate constant ( k s ) of heterogeneous electron transfer reaction for DA is estimated to be 2.7×10 –6 cm/s by cyclic voltammetry. Montmorillonite has been modified on carbon fiber electrodes, and voltammetric response of some neurotransmitters and their metabolites has been examined. The variation of DA concentration in a rat brain with decreasing blood supply has been detected when the modified microelectrode is used in in vivo experiments.