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Ultrasmall Enzyme Electrodes with Response Time Less than 100 Milliseconds
Author(s) -
Meyerhoff Joanna B.,
Ewing Michael A.,
Ewing Andrew G.
Publication year - 1999
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/(sici)1521-4109(199905)11:5<308::aid-elan308>3.0.co;2-k
Subject(s) - response time , electrode , glucose oxidase , materials science , millisecond , platinum , biosensor , limiting , analytical chemistry (journal) , chemistry , nanotechnology , chromatography , computer science , biochemistry , mechanical engineering , computer graphics (images) , astronomy , engineering , physics , catalysis
Glucose sensors with submicrometer tip diameter have been constructed by use of platinum‐deposited flame etched carbon fiber electrodes. These electrodes have been coated with glucose oxidase and result in response times as low as 85 ms. Moreover, there is a linear relationship between sensor tip diameter and response time. Although the response is, at present, only stable over a limited number of flow injection analysis runs, it appears that sensors with tip diameter less than 100 nm might provide response times of a few milliseconds if enzyme kinetics do not become rate limiting.