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Detection of S‐Enantiomers of Cilazapril, Pentopril and Trandolapril Using a Potentiometric, Enantioselective Membrane Electrode
Author(s) -
Stefan RalucaIoana,
van Staden Jacobus Koos F,
AboulEnein Hassan Y
Publication year - 1999
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/(sici)1521-4109(199903)11:3<192::aid-elan192>3.0.co;2-o
Subject(s) - potentiometric titration , chemistry , cilazapril , enantioselective synthesis , detection limit , chromatography , electrode , membrane , enantiomer , nuclear chemistry , stereochemistry , organic chemistry , catalysis , biochemistry , medicine , radiology , blood pressure , angiotensin converting enzyme , ace inhibitor
A potentiometric, enantioselective membrane electrode based on graphite paste (graphite powder and paraffin oil), impregnated with 10 −3 mol/L 2‐hydroxy‐3‐trimethylammoniopropyl‐β‐cyclodextrin (as chloride salt) solution, has been constructed. The potentiometric, enantioselective membrane electrode can be used reliably for the enantiopurity tests of S‐cilazapril ( I ), S‐pentopril ( II ) and S‐trandolapril ( III ) in the concentration range of 10 −5 –10 −2 ( I ), 10 −6 –10 −2 ( II ), 10 −4 –10 −2 mol/L ( III ), a detection limit of 5.0×10 −6 ( I ), 5.0×10 −7 ( II ), 7.58×10 −5 mol/L ( III ) and with an average recovery of 99.36 %(RSD=0.27 %) ( I ), 99.79 % (RSD=0.17 %) ( II ), 99.77 %(RSD=0.22 %) ( III ), using a chronopotentiometric (zero current) technique. The enantioselectivity was determined versus D ‐proline. It was shown that L ‐proline is the main interfering compound. The surface of the electrode can be regenerated by simply polishing it to obtain a fresh surface which is ready to be used in a new assay.