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Electrochemical Reduction of Prilocaine as its N ‐Nitrosamine Derivative at the Mercury Electrode
Author(s) -
San Martín FernándezMarcote M.,
Callejón Mochón M.,
Jiménez Sánchez J. C.,
Guiraúm Pérez A.
Publication year - 1998
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/(sici)1521-4109(199806)10:7<492::aid-elan492>3.0.co;2-3
Subject(s) - polarography , chemistry , dropping mercury electrode , prilocaine , electrochemistry , nitrosamine , aqueous solution , derivative (finance) , electrode , inorganic chemistry , organic chemistry , anesthesia , carcinogen , lidocaine , financial economics , economics , medicine
The polarographic behavior of prilocaine as its N ‐nitrosamine derivative, was studied using several electrochemical techniques. In acidic media, a nonreversible diffusion controlled reduction process involving two electrons takes place (E 1/2 =−0.86 V at pH 3.5). A differential pulse polarographic method is described for determining prilocaine based on the formation of its N ‐nitrosamine derivative in aqueous solution. The method has been validated for a series of artificial matrices where different functional groups are present. It was also applied to a pharmaceutical formulation.