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“Bite‐and‐Switch” Approach to Creatine Recognition by Use of Molecularly Imprinted Polymers
Author(s) -
Subrahmanyam S.,
Piletsky S. A.,
Piletska E. V.,
Chen B.,
Day R.,
Turner A. P. F.
Publication year - 2000
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/(sici)1521-4095(200005)12:10<722::aid-adma722>3.0.co;2-a
Subject(s) - molecularly imprinted polymer , imprinting (psychology) , polymer , molecular recognition , materials science , molecular imprinting , creatine , polymerization , nanotechnology , combinatorial chemistry , organic chemistry , biochemistry , chemistry , composite material , molecule , selectivity , catalysis , gene
The detection of creatine is important in the analysis of athletes and body builders. Here is reported the preparation of a synthetic polymer using imprinting polymerization, which leaves the polymer with receptor‐mimicking recognition sites that are specific for creatine. Molecular recognition results in a fluorescent complex (see Figure) and thus represents a “bite‐and‐switch” mechanism.