Premium
Enzyme‐Assisted Nanoscale Lithography in Lipid Membranes
Author(s) -
ClausenSchaumann Hauke,
Grandbois Michel,
Gaub Hermann E.
Publication year - 1998
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/(sici)1521-4095(199808)10:12<949::aid-adma949>3.0.co;2-0
Subject(s) - membrane , materials science , phospholipid , nanoscopic scale , nanotechnology , enzyme , lithography , artificial enzyme , lipid bilayer , biochemistry , chemistry , optoelectronics
Combining biological tools with nanotechnology: The use of a lipolytic enzyme together with an atomic force microscope to locally hydrolyze supported phospholipid membranes is reported. The Figure illustrates how the enzyme cleaves one fatty acid off the glycerol backbone by pulling the lipid out of the membrane. This enzyme‐assisted lithography method can be used to structure artificial as well as natural cell membranes.