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The Crystal Structure of 3β,14β,20‐Trihydroxy‐18oic(18 → 20)lactone pregnen‐5, Derived from a Vietnamese Folk Medical Plant
Author(s) -
Luger P.,
Weber M.,
Dung N. X.,
Thanh Ky P.,
Le The C.
Publication year - 1998
Publication title -
crystal research and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.377
H-Index - 64
eISSN - 1521-4079
pISSN - 0232-1300
DOI - 10.1002/(sici)1521-4079(1998)33:2<325::aid-crat325>3.0.co;2-b
Subject(s) - monoclinic crystal system , molecule , hydrogen bond , crystal structure , ring (chemistry) , chemistry , stereochemistry , intermolecular force , lactone , apocynaceae , crystallography , organic chemistry , traditional medicine , medicine
C 21 H 30 O 4 (295 K): monoclinic space group P 2 1 , a = 5.877(1), b = 14.801(1), c = 10.893(2) Å, β = 104.78(1)°, V = 916.2(2) Å 3 , D x = 1.256 g · cm —3 , Z = 2, F(000) = 376, λ(CuKα) = 1.5418 Å, μ = 0.682 mm —1 . The title compound was isolated as a further fraction from the powder of Ecdysanthera rosea Hook. et Arn. (Apocynaceae) of Vietnam, and its structure was elucidated. It was found that it is a pentacyclic steroidal molecule with 3 six‐membered and 2 five‐membered rings with the six/five and the five/five membered ring fusions beeing cis in both cases. Two intermolecular OH … O hydrogen bonds generate a two‐dimensional network, where four molecules contribute to a cyclic hydrogen bond pattern.