Premium
The Process of Metastases, Formation by Melanoma Patients during the Aftercare – Modelling with Markov Chains and Cox's Regression
Author(s) -
Küchler Ingeborg,
Thiele Sina,
Küchler Uwe,
Winter Helmut,
Wernecke KlausD.
Publication year - 2000
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/(sici)1521-4036(200005)42:2<161::aid-bimj161>3.0.co;2-p
Subject(s) - markov chain , proportional hazards model , medicine , regression , statistics , state space , melanoma , markov process , logistic regression , regression analysis , mathematics , markov model , cancer research
It is shown that the metastases states of patients with malignant melanoma during their (usually annual) postoperative care can be considered as a first order Markov chain if the state space is suitably extended. Thus, sojourn times in a state up to transition into another one can be analysed by means of Cox's proportional hazard model to find significant factors influencing these times.