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A P ‐Value for an Exact Two‐Sided Test of Hardy‐Weinberg Equilibrium
Author(s) -
Meulepas E.
Publication year - 1999
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/(sici)1521-4036(199907)41:4<499::aid-bimj499>3.0.co;2-b
Subject(s) - mathematics , hardy–weinberg principle , test statistic , statistics , continuity correction , statistic , exact test , value (mathematics) , p value , econometrics , statistical hypothesis testing , combinatorics , allele frequency , genetics , biology , poisson distribution , negative binomial distribution , gene , genotype , beta binomial distribution
A two‐tailed P ‐value is proposed for testing two‐sided departures from Hardy‐Weinberg equilibrium at a diallelic locus. The calculation of P uses the exact conditional distribution of the test statistic P , the observed number of heterozygotes in the sample. The proposed P ‐value is always two‐tailed, unlike other P ‐values proposed in the literature.