Premium
Estimation and Multiple Comparisons When There Are Missing Values with an Application in Immunology
Author(s) -
Holm Sture
Publication year - 1998
Publication title -
biometrical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 63
eISSN - 1521-4036
pISSN - 0323-3847
DOI - 10.1002/(sici)1521-4036(199807)40:3<269::aid-bimj269>3.0.co;2-#
Subject(s) - statistics , mathematics , missing data , estimation , computational biology , biology , immunology , engineering , systems engineering
A method is suggested for handling multiple comparisons in repeated measurement situations with completely random missing values. Exact results are obtained for the situation with normally distributed observations in the case of compound symmetry. The method uses grouping with respect to the positions of the missing values. It is most efficient and best suited when there are not too many measurement occasions in the longitudinal investigation.