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Investigation of α ‐glucosidase as a potential virulence factor of Candida albicans
Author(s) -
FeketeForgács Katalin,
Jeney Apor,
Varga Gábor,
Lenkey Béla
Publication year - 2000
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/(sici)1521-4028(200005)40:2<105::aid-jobm105>3.0.co;2-#
Subject(s) - virulence , candida albicans , corpus albicans , virulence factor , extracellular , intracellular , microbiology and biotechnology , biology , strain (injury) , phospholipase , mutant , enzyme , biochemistry , gene , anatomy
In this study, the α ‐glucosidase of C. albicans as a potential virulence factor was investigated. We compared the intracellular and intact‐cellular activities of two C. albicans strains: a clinical isolate (FS) and a laboratory mutant (FR) derived from the former. Although the FR strain was superior in all the virulence factors examined as well as in its in vivo virulence, similar intact‐cellular α ‐glucosidase activities were obtained for the two strains. Moreover, the intracellular α ‐glucosidase activity of the FR strain was lower than that of the FS strain. Making a survey on 20 clinical isolates of C. albicans , the α ‐glucosidase activities did not correlate with either the extracellular aspartic proteinase (EAP) or the extracellular phospholipase (EP) activities, although we found a correlation between the EAP and EP activities. In conclusion, our experiments do not support the view that the inducible α ‐glucosidase is a virulence factor of C. albicans .