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N′‐Methylniphimycin, a novel minor congener of niphimycin from Streptomyces spec. 57‐13
Author(s) -
Ivanova V.,
Schlegel R.,
Dornberger K.
Publication year - 1998
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/(sici)1521-4028(199811)38:5/6<415::aid-jobm415>3.0.co;2-z
Subject(s) - congener , chemistry , stereochemistry , mass spectrometry , nuclear magnetic resonance spectroscopy , streptomyces , actinomycetales , biology , organic chemistry , chromatography , bacteria , genetics
A novel natural niphimycin analog, N′‐methylniphimycin was isolated from the culture broth of the Streptomyces spec. 57‐13. The chemical constitution was elucidated from the physico‐chemical properties, NMR techniques and mass spectrometry to be a 36‐membered macrolide related to azalomycin F 5a , shurimycin B and RS‐22C. N′‐methylniphimycin displayed moderate activity against some yeasts and filamentous fungi.