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Depression by miconazole of heat‐induced respiratory‐deficiency in Saccharomyces cerevisiae
Author(s) -
MadeiraLopes A.,
Miranda João.
Publication year - 1998
Publication title -
journal of basic microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 54
eISSN - 1521-4028
pISSN - 0233-111X
DOI - 10.1002/(sici)1521-4028(199803)38:1<27::aid-jobm27>3.0.co;2-b
Subject(s) - miconazole , ketoconazole , saccharomyces cerevisiae , mutant , yeast , chemistry , respiratory system , mutation , mitochondrion , biochemistry , biology , microbiology and biotechnology , gene , anatomy , antifungal
Miconazole, at 0.2 μ M , decreased, by two orders of magnitude, the specific mutation rate of Saccharomyces cerevisiae to respiratory‐deficient mutants (petites), which had been induced at either 37 °C or 39 °C. Identical concentrations of ketoconazole did not change the mutation rate. The results fit in the mechanisms of action which have been proposed for imidazole antimycotics, and constitute further support for the hypothesis that the targets of thermal death, in petite‐positive associately‐profiled yeasts, lie in the mitochondria.