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Synthesis of heterotelechelic poly(ethylene glycol)s and their characterization by MALDI‐TOF‐MS
Author(s) -
Völcker Nicolas Hans,
Klee Doris,
Hanna Martin,
Höcker Hartwig,
Bou Jordi J.,
de Ilarduya Antxon Martínez,
MuñozGuerra Sebastián
Publication year - 1999
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/(sici)1521-3935(19990601)200:6<1363::aid-macp1363>3.0.co;2-a
Subject(s) - ethylene glycol , chemistry , peg ratio , polymer chemistry , end group , chemical modification , gel permeation chromatography , ion exchange , size exclusion chromatography , sephadex , chromatography , organic chemistry , polymerization , ion , polymer , finance , economics , enzyme
Two heterotelechelic poly(ethylene glycol)s were synthezised by end group modification of α ‐hydro‐ ω ‐hydroxy‐poly(oxyethylene) (PEG). The first reaction route starts from heterobifunctional α ‐hydro‐ ω ‐octadecanoyloxy‐poly(oxyethylene) (400) and comprises the synthesis of α ‐hydro‐ ω ‐carboxymethoxy‐poly(oxyethylene). The second pathway starts from homotelechelic PEG(400) and leads to α ‐(2‐propenyl)‐ ω ‐carboxymethylthio‐poly(oxyethylene). Purification of the desired products was accomplished by means of ion exchange chromatography on DEAE Sephadex. PEG derivatives were characterized by means of NMR, IR, HPLC and GPC. MALDI‐TOF‐MS recorded in the reflectron mode served as a fine method that provides information on chemical composition as well as molecular weight.