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Synthesis and characterization of hydrophilic lipopolymers for the support of lipid bilayers
Author(s) -
Hausch Marcus,
Zentel Rudolf,
Knoll Wolfgang
Publication year - 1999
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/(sici)1521-3935(19990101)200:1<174::aid-macp174>3.0.co;2-c
Subject(s) - polymer , copolymer , comonomer , polymer chemistry , monolayer , materials science , contact angle , ethylamine , acrylate , chemical engineering , chemistry , organic chemistry , nanotechnology , composite material , engineering
This paper describes a flexible synthetic route to build‐up lipopolymers. This is achieved on the basis of copolymers from different acrylamides and the acrylate of N ‐hydroxysuccinimide. Through reactions on the polymers (polymer‐analogous reactions) with DMPE (2‐(dimyristyl‐ L ‐ α ‐phosphatidyloxy)ethylamine) and 2‐aminoethyl methyl disulfide the terpolymer composition can be varied easily. The polymers obtained by this method can be used to prepare self‐assembled polymer films on gold‐coated substrates. A characterization of the self‐assembled film and of the polymeric monolayer at the water surface demonstrates the importance of the hydrophilic comonomer. Polymers including the more hydrophilic N , N ‐dimethylacrylamide allow to vary the hydrophilicity of the self‐assembled films to a large extent (contact angles varying from 35° to 72° depending on the amount of phospholipid). In addition, these films swell up to 25% in an atmosphere of 98% humidity. For obtaining hydrophilic swellable polymers to build‐up tethered supported lipid bilayers they are therefore preferable.