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Synthesis of photoreactive α‐4‐azidobenzoyl‐ω‐methoxy‐poly(ethylene glycol)s and their end‐on photo‐grafting onto polysulfone ultrafiltration membranes
Author(s) -
Thom Volkmar,
Jankova Katja,
Ulbricht Mathias,
Kops Jørgen,
Jonsson Gunnar
Publication year - 1998
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/(sici)1521-3935(19981201)199:12<2723::aid-macp2723>3.0.co;2-k
Subject(s) - polysulfone , membrane , polymer chemistry , ethylene glycol , ultrafiltration (renal) , grafting , chemistry , protein adsorption , adsorption , covalent bond , peg ratio , surface modification , contact angle , bovine serum albumin , aqueous solution , materials science , organic chemistry , chromatography , polymer , finance , biochemistry , economics , composite material
Covalent end‐on grafting of poly(ethylene glycol) (PEG) onto a polysulfone (PSf) surface using α‐4‐azidobenzoyl‐ω‐methoxy‐PEG (ABMPEG) is described. Photoreactive ABMPEG was synthesized by reacting monomethoxy‐PEG (MPEG) with 4‐azidobenzoyl chloride, yielding complete substitution of the hydroxyl groups. After adsorption from aqueous solutions, ABMPEG was photo‐grafted under wet conditions onto PSf ultrafiltration (UF) membranes. Contact angle (CA) measurements showed the increased hydrophilicity of modified membranes and the irreversibility of the modification. Bovine serum albumin (BSA) adsorption decreased by 70% and the permeability decay after protein adsorption became less severe for the modified membranes compared to unmodified reference membranes.