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Preparation of poly(methyl methacrylate) microspheres modified with amino acid moieties
Author(s) -
Shiraishi Kohei,
Ohnishi Tsunehisa,
Sugiyama Kazuo
Publication year - 1998
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/(sici)1521-3935(19980901)199:9<2023::aid-macp2023>3.0.co;2-v
Subject(s) - polymer chemistry , methyl methacrylate , copolymer , chemistry , methacrylate , poly(methyl methacrylate) , polymer , propane , materials science , organic chemistry
Poly(methyl methacrylate) microspheres [poly(SerMA‐ co ‐MMA), poly(AlaMAm‐ co ‐MMA), poly(AlaEMA‐ co ‐MMA), and poly(AlaMAm/AlaEMA‐ co ‐MMA)] modified with O ‐methacryloyl‐ L ‐serine (SerMA), N ‐methacryloyl‐ L ‐alanine (AlaMAm) and L ‐alanine 2‐methacryloyloxyethyl ester (AlaEMA) were prepared by the emulsifier‐free emulsion copolymerization of methyl methacrylate (MMA) with SerMA, AlaMAm and AlaEMA, respectively, initiated with 2,2′‐azobis[2‐(2‐imidazolin‐2‐yl)propane] dihydrochloride (ABIP). The series of polymer microspheres showed unimodal distribution of the particle size (290–800 nm) in water. From X‐ray photoelectron spectroscopy it was concluded that the amino acid moieties are located on the surface of the particles in all cases. Poly(SerMA‐ co ‐MMA) showed the most effective suppression of adsorption of proteins such as albumin (Alb), γ‐globulin (Glo) and fibrinogen (Fib) among the examined poly(methylmethacrylate) microspheres.