Premium
A new class of biodegradable hydrogels stereocomplexed by enantiomeric oligo(lactide) side chains of poly(HEMA‐ g ‐OLA)s
Author(s) -
Lim Dong Woo,
Choi Seung Ho,
Park Tae Gwan
Publication year - 2000
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/(sici)1521-3927(20000501)21:8<464::aid-marc464>3.0.co;2-#
Subject(s) - self healing hydrogels , polymer chemistry , lactide , side chain , enantiomer , polymer science , chemistry , materials science , copolymer , organic chemistry , polymer
Two enantiomeric amphiphilic graft copolymers consisting of water soluble poly(2‐hydroxyethyl methacrylate) (HEMA) and biodegradable oligo( L ‐lactide) (OLLA) or oligo( D ‐lactide) (ODLA) were synthesized by free radical copolymerization. HEMA‐OL(D)LA macromonomers were synthesized by ring opening polymerization of L ‐ or D ‐lactide. Both HEMA‐OLA macromonomers and graft copolymers were characterized by NMR spectroscopy and gel permeation chromatography. Graft copolymers and their stereocomplexes were analyzed by wide angle X‐ray diffraction and differential scanning calorimetry (DSC). Due to the formation of stereocomplex crosslinks between poly(HEMA) main chains, amphiphilic, biodegradable hydrogels prepared by blending of two enantiomeric poly(HEMA‐ g ‐OLLA) and poly(HEMA‐ g ‐ODLA) degraded more slowly in phosphate buffered saline than individual optically pure poly‐(HEMA‐ g ‐OL(D)LA).