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Synthesis of poly( O ‐phospho‐ L ‐serine) and its structure in aqueous solution
Author(s) -
Ohkawa Kousaku,
Saitoh Arihiro,
Yamamoto Hiroyuki
Publication year - 1999
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/(sici)1521-3927(19991201)20:12<619::aid-marc619>3.0.co;2-n
Subject(s) - aqueous solution , polymerization , serine , circular dichroism , polymer chemistry , yield (engineering) , chemistry , polymer , aqueous medium , crystallography , materials science , phosphorylation , organic chemistry , biochemistry , metallurgy
A novel polypeptide, poly( O ‐phospho‐ L ‐Ser), was synthesized through the following three steps: i) preparation of O ‐diphenylphospho‐ L ‐serine N ‐carboxyanhydride [Ser(PPh 2 ) NCA]; ii) polymerization of Ser(PPh 2 ) NCA; iii) removal of phenyl groups from poly[Ser(PPh 2 )]. The overall yield in the three‐ step synthesis was 71%, and the phospho‐Ser content in poly( O ‐phospho‐ L ‐Ser) was 98 ± 1%. Circular dichroism spectra suggest that the polypeptide has two different disordered structures in aqueous solution.