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Poly( N ‐isopropylacrylamide) with hydrolyzable lactic acid ester side groups: a new type of thermosensitive polymer
Author(s) -
Neradovic Dragana,
Hinrichs Wouter L. J.,
Kettenesvan den Bosch Jantien J.,
Hennink Wim E.
Publication year - 1999
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/(sici)1521-3927(19991101)20:11<577::aid-marc577>3.0.co;2-d
Subject(s) - lower critical solution temperature , copolymer , polymer chemistry , poly(n isopropylacrylamide) , methacrylate , hydrolysis , aqueous solution , polymer , chemistry , materials science , organic chemistry
N ‐isopropylacrylamide (NIPAAm) was copolymerized with 2‐hydroxyethyl methacrylate‐monolactate (HEMA‐monolactate). With increasing HEMA‐monolactate content in the copolymer, the lower critical solution temperature (LCST) decreases. During incubation in an aqueous solution, the lactate groups are released by hydrolysis, by which the copolymer is converted into poly(NIPAAm‐ co ‐HEMA). By this process, the hydrophilicity of the copolymer increases, resulting in increased LCST values.