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Synthesis of a new poly(carboxybetaine) with peptide main chain
Author(s) -
Nagaya Jiro,
Uzawa Hirotaka,
Minoura Norihiko
Publication year - 1999
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/(sici)1521-3927(19991101)20:11<573::aid-marc573>3.0.co;2-t
Subject(s) - side chain , betaine , polymer chemistry , peptide , chemistry , intrinsic viscosity , polymer , organic chemistry , biochemistry
A new poly(carboxybetaine) whose main chain is composed of peptide bonds was synthesized from poly( γ ‐methyl L ‐glutamate). The side chains of poly( γ ‐methyl L ‐glutamate) were exchanged to carboxybetaine structures by three reactions. Our new poly(carboxybetaine) has 84% carboxybetaine structures in the side chains, as determined by 1 H NMR measurements. The presence of betaine structures in the side chains was confirmed by viscosity measurements.