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Ring‐opening precipitation polymerization of poly( D , L ‐lactide‐ co ‐glycolide) in supercritical carbon dioxide
Author(s) -
Hile David D.,
Pishko Michael V.
Publication year - 1999
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/(sici)1521-3927(19991001)20:10<511::aid-marc511>3.0.co;2-q
Subject(s) - dispersity , supercritical carbon dioxide , supercritical fluid , polymerization , precipitation polymerization , polymer , polymer chemistry , lactide , monomer , gel permeation chromatography , materials science , ring opening polymerization , supercritical fluid extraction , precipitation , chemical engineering , radical polymerization , chemistry , organic chemistry , composite material , physics , meteorology , engineering
The biodegradable polymer poly( D , L ‐lactide‐ co ‐glycolide) was synthesized by a ring‐opening precipitation polymerization in supercritical CO 2 using stannous octoate as initiator. Following polymerization, unreacted monomer was removed by supercritical fluid extraction and the polymer was recovered as a porous solid upon depressurization of the CO 2 phase. The lactide to glycolide ratio of the polymer was determined to be 70.7 : 29.3 using 13 C NMR spectroscopy. The weight‐average molecular weight of the product was measured to be 3 500, with a polydispersity of 1.4 using gel permeation chromatography.