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Novel pH‐sensitive polymers containing sulfonamide groups
Author(s) -
Park Sang Yeob,
Bae You Han
Publication year - 1999
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/(sici)1521-3927(19990501)20:5<269::aid-marc269>3.0.co;2-3
Subject(s) - sulfonamide , polymer , chemistry , combinatorial chemistry , polymer chemistry , organic chemistry
Novel pH‐sensitive polymers were synthesized by copolymerizing a monomer derivatized from 4‐amino‐ N ‐[4,6‐dimethyl‐2‐pyrimidinyl]benzene sulfonamide with N , N ‐dimethylacrylamide. The linear copolymers showed pH‐sensitive solubility, while chemically crosslinked hydrogels exhibit a relatively sharp transition in swelling around physiological pH. These changes were found to be reversible. By varying the type of sulfonamide and the copolymer composition, a new class of pH‐sensitive polymers with a broad range of transition pH can be synthesized.