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Thermally induced core‐shell type hydrogel beads having interpenetrating polymer network (IPN) structure
Author(s) -
Park Tae Gwan,
Choi Hoo Kyun
Publication year - 1998
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/(sici)1521-3927(19980401)19:4<167::aid-marc167>3.0.co;2-g
Subject(s) - interpenetrating polymer network , materials science , polymer , dispersity , core (optical fiber) , chemical engineering , shell (structure) , self healing hydrogels , poly(n isopropylacrylamide) , polymer chemistry , composite material , copolymer , engineering
Monodisperse hydrogel beads composed of calcium alginate and crosslinked polyNIPAAm ( N ‐isopropylacrylamide) were synthesized based on a simultaneous interpenetrating network process. With increasing the temperature above the phase transition temperature of polyNIPAAm, a core‐shell type of hydrogel beads was developed; polyNIPAAm‐enriched core region and Ca‐alginate‐enriched outer shell layer were observed. The thermally reversible formation of the core‐shell double structure in the IPN hydrogel beads was applied for the temperature modulated drug release using indomethacin as a model drug.