Premium
Conjugates of polylysine and oligo( N , N ‐diethylacrylamide) as temperature‐sensitive agents in DNA condensation
Author(s) -
Bromberg Lev,
Levin Gideon
Publication year - 1998
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/(sici)1521-3927(19980101)19:1<79::aid-marc79>3.0.co;2-8
Subject(s) - lower critical solution temperature , conjugate , polylysine , dispersity , polymer chemistry , polymerization , conjugated system , chemistry , poly(n isopropylacrylamide) , stoichiometry , materials science , polymer , copolymer , organic chemistry , mathematical analysis , mathematics
Carboxy‐terminated oligomers of N , N ‐diethylacrylamide (DEAAm) of low polydispersity were synthesized by group‐transfer polymerization. The oligomers were conjugated with polylysine. The resulting conjugates possessed lower critical solution temperatures (LCST) around 29°C. Non‐stoichiometric conjugate‐DNA complexes reversibly precipitated above the conjugate's LCST.