Premium
Formation of stable polymeric vesicles by tocopherol‐containing amphiphiles
Author(s) -
Cho Iwhan,
Kim YoungDae
Publication year - 1998
Publication title -
macromolecular rapid communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 154
eISSN - 1521-3927
pISSN - 1022-1336
DOI - 10.1002/(sici)1521-3927(19980101)19:1<27::aid-marc27>3.0.co;2-u
Subject(s) - vesicle , amphiphile , monomer , polymer chemistry , polymerization , gel permeation chromatography , chemistry , aqueous solution , copolymer , materials science , polymer , organic chemistry , membrane , biochemistry
Polymeric vesicles were obtained by a free radical polymerization of aqueous dispersions of the tocopherol‐containing nonionic single‐chain amphiphile 3 synthesized by the reaction of O ‐tocopheryloligo(oxyethylene) chloroacetate ( 2 ) and 2‐( N , N ‐dimethylamino)ethyl methacrylate. Weight‐average molar masses ( M̄ w ) of the polymeric vesicles estimated by gel permeation chromatography are in the range of 75000–115000. The phase transition temperature ( T c ) of the polymeric vesicles is 77°C, which is higher than that of the monomeric vesicles, 51°C. Transmission electron microscopy photographs show that the polymerization of monomeric vesicles of 3 leads to the formation of mostly polymeric, elliptic vesicles of distinct morphology having short axes of ca. 300–1200 Å and long axes of ca. 600–2400 Å. The polymeric vesicles exhibit an enhanced stability compared with their monomeric counterparts.