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A Structural Model for the Galactose Oxidase Active Site which Shows Counteranion‐Dependent Phenoxyl Radical Formation by Disproportionation
Author(s) -
Shimazaki Yuichi,
Huth Stefan,
Odani Akira,
Yamauchi Osamu
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000502)39:9<1666::aid-anie1666>3.0.co;2-o
Subject(s) - disproportionation , galactose oxidase , ligand (biochemistry) , chemistry , counterion , active site , radical , photochemistry , galactose , stereochemistry , enzyme , ion , biochemistry , catalysis , organic chemistry , receptor
A novel tetradentate ligand has been shown to react with Cu(OAc) 2 to form 1 , which mimics the active‐site structure of galactose oxidase. The reaction of the ligand with Cu II depends on the counterions available; the Cu(ClO 4 ) 2 ligand system gives a phenoxyl radical species and [Cu(CH 3 CN) 4 ]ClO 4 by a disproportionation reaction (see scheme).