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First Noncovalently Bound Calix[4]arene–Gd III –Albumin Complex
Author(s) -
Bryant, Jr. L. Henry,
Yordanov Alexander T.,
Linnoila Jenny J.,
Brechbiel Martin W.,
Frank Joseph A.
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000502)39:9<1641::aid-anie1641>3.0.co;2-l
Subject(s) - human serum albumin , chemistry , gadolinium , mri contrast agent , albumin , calixarene , relaxation (psychology) , nuclear magnetic resonance , stereochemistry , organic chemistry , chromatography , biochemistry , molecule , medicine , physics
The gadolinium( III ) complex of the new water‐soluble calix[4]arene tetraamide 1 is the first calix[4]arene that noncovalently binds to human serum albumin (HSA), as confirmed by nuclear magnetic relaxation dispersion experiments. Thus, in principle, it should be suitable as a contrast agent for NMR imaging applications.