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Nickel‐Catalyzed Cross‐Coupling of Aryl Chlorides with Aryl Grignard Reagents
Author(s) -
Böhm Volker P. W.,
Weskamp Thomas,
Gstöttmayr Christian W. K.,
Herrmann Wolfgang A.
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000502)39:9<1602::aid-anie1602>3.0.co;2-n
Subject(s) - aryl , catalysis , nickel , carbene , halide , reagent , chemistry , magnesium , combinatorial chemistry , coupling (piping) , organic chemistry , materials science , alkyl , metallurgy
The ambient temperature Grignard cross‐coupling of aryl chlorides with aryl magnesium halides [Eq. (1)] is made possible for the first time by nickel catalysts containing bulky N‐heterocyclic carbene or bulky phosphane ligands. A 19 F NMR spectroscopic screening assay with fluorinated aryl chlorides was employed to achieve a rapid identification and optimization of high‐performance catalysts. acac = acetylacetonate.