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Asymmetric Synthesis of an Organic Compound with High Enantiomeric Excess Induced by Inorganic Ionic Sodium Chlorate
Author(s) -
Sato Itaru,
Kadowaki Kousuke,
Soai Kenso
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000417)39:8<1510::aid-anie1510>3.0.co;2-r
Subject(s) - sodium chlorate , enantioselective synthesis , chlorate , chemistry , enantiomer , sodium , enantiomeric excess , ionic bonding , medicinal chemistry , inorganic chemistry , stereochemistry , organic chemistry , catalysis , ion
Morphologically chiral crystals of sodium chlorate induce highly enantioselective synthesis. Thus the addition of diisopropylzinc to 2‐( tert ‐butylethynyl)pyrimidine‐5‐carbaldehyde in the presence of d ‐ and l ‐NaClO 3 gives the ( S )‐ and ( R )‐alkanol, respectively, in high yields and with high ee values (see scheme).