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A New Biosynthetic Pathway to Alkaloids in Plants: Acetogenic Isoquinolines
Author(s) -
Bringmann Gerhard,
Wohlfarth Michael,
Rischer Heiko,
Grüne Matthias,
Schlauer Jan
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000417)39:8<1464::aid-anie1464>3.0.co;2-#
Subject(s) - chemistry , stereochemistry , computational biology , biology
Built up from acetate , dioncophylline A is the only acetogenic tetrahydroisoquinoline alkaloid as yet known (see scheme). This new biosynthetic pathway was proved by feeding experiments with [ 13 C 2 ]acetate.