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Synthesis of the First Selective Irreversible Inhibitor of Neutral Sphingomyelinase
Author(s) -
Arenz Christoph,
Giannis Athanassios
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000417)39:8<1440::aid-anie1440>3.0.co;2-r
Subject(s) - ceramide , sphingomyelin , sphingolipid , acid sphingomyelinase , lipid signaling , sphingomyelin phosphodiesterase , second messenger system , chemistry , microbiology and biotechnology , function (biology) , biochemistry , biology , signal transduction , enzyme , membrane , apoptosis
The sphingolipid ceramide has been discusssed for some time as a possible secondary messenger for a number of physiological and pathalogical processes, including autoimmune diseases of the central nervous system, such as multiple sclerosis. Ceramide can be activated through the action of acid or neutral sphingomyelinases. The spiroepoxide 1 is the first selective irreversible inhibitor of neutral sphingomyelinase and will, therefore, be useful in the elucidation of the biological function of ceramide.