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Stereoselective Combinatorial Ugi‐Multicomponent Synthesis on Solid Phase
Author(s) -
Oertel Kai,
Zech Gernot,
Kunz Horst
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000417)39:8<1431::aid-anie1431>3.0.co;2-n
Subject(s) - solid phase synthesis , stereoselectivity , ugi reaction , combinatorial chemistry , combinatorial synthesis , phase (matter) , component (thermodynamics) , chemistry , materials science , stereochemistry , isocyanide , organic chemistry , physics , thermodynamics , biochemistry , peptide , catalysis
Stereoselectively on solid phase : the Ugi four‐component reaction, which because of its high potential for the generation of molecular diversity is particularly important in combinatorial synthesis, has been accomplished in this way for the first time by using a polymer‐linked galactosylamine ( 1 ) bound through a suitable anchor and spacer. Piv=pivaloyl= t BuCO.