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Enantioselective β ‐Amino Acid Synthesis Based on Catalyzed Asymmetric Acyl Halide – Aldehyde Cyclocondensation Reactions
Author(s) -
Nelson Scott G.,
Spencer Keith L.
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000403)39:7<1323::aid-anie1323>3.0.co;2-x
Subject(s) - enantioselective synthesis , aldehyde , sn2 reaction , chemistry , halide , catalysis , amine gas treating , organic chemistry , combinatorial chemistry
N‐Protected β ‐amino acids are obtained from an operationally simple, two‐step enantioselective synthesis, which integrates aluminum‐catalyzed asymmetric acyl halide – aldehyde cyclocondensation reactions with amine‐mediated S N 2 ring opening of the derived enantiomerically enriched β ‐lactones (see scheme).