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Photocontrol of Triple‐Helix Formation by Using Azobenzene‐Bearing Oligo(thymidine)
Author(s) -
Asanuma Hiroyuki,
Liang Xingguo,
Yoshida Takayuki,
Yamazawa Akira,
Komiyama Makoto
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000403)39:7<1316::aid-anie1316>3.0.co;2-h
Subject(s) - azobenzene , triple helix , moiety , helix (gastropod) , chemistry , stereochemistry , crystallography , molecule , biology , organic chemistry , ecology , snail
Upon irradiation, reversible modulation of triple‐helix formation occurs. A model double helix is formed from oligo(T) and oligo(dA). In the presence of a second oligo(T) modified with an azobenzene moiety, the binding strength of the triple helix is dependent upon the configuration of the azobenzene, a feature controlled by light (see picture). The length of the oligomers and position of the azobenzene affect the helix‐binding strength.