Premium
Thioxylation as One‐Atom‐Substitution Generates a Photoswitchable Element within the Peptide Backbone
Author(s) -
Frank Robert,
Jakob Mario,
Thunecke Frank,
Fischer Gunter,
Schutkowski Mike
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000317)39:6<1120::aid-anie1120>3.0.co;2-h
Subject(s) - isomerization , chemistry , peptide , peptide bond , stereochemistry , substitution (logic) , combinatorial chemistry , organic chemistry , biochemistry , catalysis , computer science , programming language
The introduction of a thioxo peptide bond in agonists of the opioid μ ‐receptor lead to bioactive derivatives. The backbone conformation of these compounds can be specifically modulated by photoinduction of the cis / trans prolyl bond isomerization [Eq. (1)].