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Pseudoprolines: Targeting a cis Conformation in a Mimetic of the gp120 V3 Loop of HIV‐1
Author(s) -
Wittelsberger Angela,
Keller Michael,
Scarpellino Leo,
Patiny Luc,
AchaOrbea Hans,
Mutter Manfred
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000317)39:6<1111::aid-anie1111>3.0.co;2-d
Subject(s) - v3 loop , chemistry , peptide , thiazolidine , derivative (finance) , stereochemistry , human immunodeficiency virus (hiv) , loop (graph theory) , cyclic peptide , computational biology , biochemistry , biology , peptide sequence , virology , mathematics , combinatorics , economics , financial economics , gene
The specific recognition of cis peptide bonds is possible with antibodies that are directed against cyclic and linear peptide antigens derived from the V3 loop of the HIV‐1 protein gp120, into which a thiazolidine derivative (pseudoproline) has been introduced (see schematic representation). This extension of the pseudoproline concept may help to decipher the unique role of proline residues in biologically relevant systems.