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Tin‐Free Radical Cyclization Reactions Using the Persistent Radical Effect
Author(s) -
Studer Armido
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000317)39:6<1108::aid-anie1108>3.0.co;2-a
Subject(s) - tin , nitrile , chemistry , radical cyclization , aryl , radical initiator , alcohol , radical , free radical reaction , combinatorial chemistry , organic chemistry , polymer chemistry , photochemistry , alkyl , polymerization , polymer
Environmentally benign tin‐free radical cyclization reactions allow the preparation of cyclic alcohol derivatives. The isomerizations are very easy to conduct and proceed in high yields for alkoxyamines with weak C−O bonds [Eq. (1); R=Ph, functionalized aryl, heteroaryl, ester, or nitrile group]. As a first application of the new method, the preparation of a complex tetracycle is presented.