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Novel Zinc Fluorescent Probes Excitable with Visible Light for Biological Applications
Author(s) -
Hirano Tomoya,
Kikuchi Kazuya,
Urano Yasuteru,
Higuchi Tsunehiko,
Nagano Tetsuo
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000317)39:6<1052::aid-anie1052>3.0.co;2-5
Subject(s) - fluorophore , fluorescence , zinc , chemistry , photochemistry , organic chemistry , optics , physics
Fluorophore plus a macrocyclic polyamine blend into a probe for zinc that is active under physiological conditions. Compound 1 (X=Cl) increased fluorescence intensity 26‐fold upon addition of Zn II , yet is insensitive to other common metals. The probes are active at a range of pH values, most importantly at pH 7. These probes do not need biologically harmful UV irradiation for fluoroescent activity.