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Metal Ions as Allosteric Inhibitors in Hydrogen‐Bonding Receptors
Author(s) -
AlSayah Mohammad H.,
Branda Neil R.
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000303)39:5<945::aid-anie945>3.0.co;2-e
Subject(s) - hydrogen bond , allosteric regulation , chemistry , chelation , bipyridine , metal , copper , carboxylate , metal ions in aqueous solution , triazine , ion , inorganic chemistry , combinatorial chemistry , molecule , stereochemistry , receptor , crystallography , polymer chemistry , crystal structure , organic chemistry , biochemistry
The presence of copper( I ) ions turns off the recognition of uracil and carboxylate derivatives (the “guest”) by bis(bipyridine)triazine and bis(bipyridine)urea receptors (shown schematically). These negative allosteric processes are driven by the complexation of the metal to the chelating ligands, which distorts the hydrogen‐bonding surfaces.