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Electrochemical Transduction of Liposome‐Amplified DNA Sensing
Author(s) -
Patolsky Fernando,
Lichtenstein Amir,
Willner Itamar
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000303)39:5<940::aid-anie940>3.0.co;2-y
Subject(s) - dielectric spectroscopy , electrode , transduction (biophysics) , electrochemistry , dna , biosensor , liposome , electron transfer , redox , chemistry , materials science , nanotechnology , biophysics , photochemistry , inorganic chemistry , biochemistry , biology
The formation of double‐stranded DNA on electrodes can be probed and amplified with functionalized liposomes (shown schematically). The resulting charged interface strongly repels the redox label, [Fe(CN) 6 ] 3− /[Fe(CN) 6 ] 4− , from the electrode interface, resulting in a high electron transfer resistance. Faradaic impedance spectroscopy is used to transduce the biosensing events.