Premium
Simple Synthesis of Tetra‐Acceptor‐Substituted Alkenes by the Formal Dehydrodimerization of Malonates
Author(s) -
Linker Torsten,
Linker Ursula
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000303)39:5<902::aid-anie902>3.0.co;2-5
Subject(s) - tetra , acceptor , knoevenagel condensation , chemistry , simple (philosophy) , combinatorial chemistry , reaction conditions , organic chemistry , catalysis , medicinal chemistry , physics , condensed matter physics , philosophy , epistemology
Only two steps are required for the synthesis of tetra‐acceptor‐substituted alkenes from simple malonates in excellent yields [Eq. (1)]. The method is characterized by cheap and commercially available precursors, and ultrasound remarkably accelerates the radical reaction as well as the successive Knoevenagel reaction.