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The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin
Author(s) -
Lombó Felipe,
Künzel Eva,
Prado Laura,
Braña Alfredo F.,
Bindseil Kai U.,
Frevert Jürgen,
Bearden Dan,
Méndez Carmen,
Salas José A.,
Rohr Jürgen
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000218)39:4<796::aid-anie796>3.0.co;2-n
Subject(s) - biosynthesis , tricyclic , chemistry , antibiotics , combinatorial chemistry , gene , optically active , biochemistry , stereochemistry , organic chemistry
Gene recombination experiments are not only useful for the generation of novel hybrid natural products, but can also be helpful in intercepting unstable biosynthetic intermediates to allow conclusions to be made about their structures. Premithramycinone H ( 1 ), a biologically active hybrid which results from a mixture of mithramycin and tetracenomycin biosynthetic genes, is a good example of this strategy.