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Solid‐Supported Hydrazine Substrate For Labeling Estradiol Ligands with Rhenium
Author(s) -
Arterburn Jeffrey B.,
Rao Kalla Venkateswara,
Perry Marc C.
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(20000218)39:4<771::aid-anie771>3.0.co;2-e
Subject(s) - rhenium , reagent , ligand (biochemistry) , chemistry , combinatorial chemistry , steroid , substrate (aquarium) , hydrazine (antidepressant) , chromatography , radiochemistry , inorganic chemistry , organic chemistry , receptor , biochemistry , biology , hormone , ecology
Convenient “instant kits” for preparing receptor‐targeted radiopharmaceuticals may be achievable through the labeling of estradiol with rhenium radionuclides. This method is simplified with the solid‐phase reagent shown schematically. The reagent binds the steroid ligand, establishes the steroid – radioisotope linkage, and releases the labeled product into solution, thus facilitating removal of unlabeled ligand by filtration.